Small, Clonally Variant Antigens Expressed on the Surface of the Plasmodium falciparum– Infected Erythrocyte Are Encoded by the rif Gene Family and Are the Target of Human Immune Responses

Abstract excerpt

Disease severity in Plasmodium falciparum infections is a direct consequence of the parasite's efficient evasion of the defense mechanisms of the human host. To date, one parasite-derived molecule, the antigenically variant adhesin P. falciparum erythrocyte membrane protein 1 (PfEMP1), is known to be transported to the infected erythrocyte (pRBC) surface, where it mediates binding to different host receptors....

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