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Recognition of Variant Rifin Antigens by Human Antibodies Induced during Natural Plasmodium falciparum Infections

18 Nov 2002

Abstract excerpt

Antibodies from individuals living in areas where malaria is endemic are known to react with parasite-derived erythrocyte surface proteins. The major immunogenic and clonally variant surface antigen described to date is Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP-1), which is encoded by members of the multicopy var gene family. We report here that rifin proteins (RIF proteins), belonging to the...

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PMID: 12438381
DOI: 10.1128/iai.70.12.7013-7021.2002

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