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Article

Bicaudal-C associates with a Trailer Hitch/Me31B complex and is required for efficient Gurken secretion.

Developmental biology - 1 Apr 2009

Kugler Jan-Michael, Chicoine Jarred, Lasko Paul

Abstract excerpt

Bicaudal-C (Bic-C) is a multiple KH-domain RNA-binding protein required for Drosophila oogenesis and, maternally, for embryonic patterning. In early oogenesis, Bic-C negatively regulates target mRNAs, including Bic-C, by recruiting the CCR4 deadenylase through a direct association with its NOT3 subunit. Here, we identify a novel function for Bic-C in secretion of the TGF-alpha homolog Gurken (Grk). In Bic-C...

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Source

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Identifiers

PMID: 19389362
DOI: 10.1016/j.ydbio.2009.01.024
PMCID: PMC2684517

Genes

CCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Bicaudal-C associates with a Trailer Hitch/Me31B complex and is required for efficient Gurken secretion.PMID 19389362Read ↗

Bicaudal C and trailer hitch have similar roles in gurken mRNA localization and cytoskeletal organization.Semantic proximity Read ↗

Bicaudal-C recruits CCR4-NOT deadenylase to target mRNAs and regulates oogenesis, cytoskeletal organization, and its own expression.Semantic proximity Read ↗

The transmembrane region of Gurken is not required for biological activity, but is necessary for transport to the oocyte membrane in Drosophila.Semantic proximity Read ↗

Combined activities of Gurken and decapentaplegic specify dorsal chorion structures of the Drosophila egg.Semantic proximity Read ↗

Premature translation of oskar in oocytes lacking the RNA-binding protein bicaudal-C.Semantic proximity Read ↗

Localized Bicaudal-C RNA encodes a protein containing a KH domain, the RNA binding motif of FMR1.Semantic proximity Read ↗

Post-transcriptional regulation of gurken by encore is required for axis determination in Drosophila.Semantic proximity Read ↗

Evidence for a transport-trap mode of Drosophila melanogaster gurken mRNA localization.Semantic proximity Read ↗

Drosophila Hephaestus/polypyrimidine tract binding protein is required for dorso-ventral patterning and regulation of signalling between the germline and soma.Semantic proximity Read ↗

Encore is a member of a novel family of proteins and affects multiple processes in Drosophila oogenesis.Semantic proximity Read ↗

Trailer Hitch tunes condensate phase behavior and mRNA partitioning to regulate P-body homeostasis during <i>Drosophila melanogaster</i> oogenesisSemantic proximity Read ↗

The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein.Semantic proximity Read ↗

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