Article
DNA transport by a micromachined Brownian ratchet device.
Proceedings of the National Academy of Sciences of the United States of America - 9 Nov 1999
Bader J S, Hammond R W, Henck S A, Deem M W, McDermott G A, Bustillo J M, Simpson J W, Mulhern G T, Rothberg J M
Abstract excerpt
We have micromachined a silicon-chip device that transports DNA with a Brownian ratchet that rectifies the Brownian motion of microscopic particles. Transport properties for a DNA 50-mer agree with theoretical predictions, and the DNA diffusion constant agrees with previous experiments. This type of micromachine could provide a generic pump or separation component for DNA or other charged species as part of a...
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