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Article

Role of protein kinase C-alpha in the control of infection by intracellular pathogens in macrophages.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1999

St-Denis A, Caouras V, Gervais F, Descoteaux A

Abstract excerpt

The protein kinase C (PKC) family regulates macrophage function involved in host defense against infection. In this study, we investigated the role of macrophage PKC-alpha in the uptake and subsequent fate of Leishmania donovani promastigotes and Legionella pneumophila infections. To this end, we used clones of the murine macrophage cell line RAW 264.7 overexpressing a dominant-negative (DN) mutant of PKC-alpha....

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PMID: 10553077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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