Article
The Aspergillus fumigatus pkcA G579R Mutant Is Defective in the Activation of the Cell Wall Integrity Pathway but Is Dispensable for Virulence in a Neutropenic Mouse Infection Model.
PloS one - 1 Jan 2015
Rocha Marina Campos, Godoy Krissia Franco de, de Castro Patrícia Alves, Hori Juliana Issa, Bom Vinícius Leite Pedro, Brown Neil Andrew, Cunha Anderson Ferreira da, Goldman Gustavo Henrique, Malavazi Iran
Abstract excerpt
Aspergillus fumigatus is an opportunistic human pathogen, which causes the life-threatening disease, invasive pulmonary aspergillosis. In fungi, cell wall homeostasis is controlled by the conserved Cell Wall Integrity (CWI) pathway. In A. fumigatus this signaling cascade is partially characterized, but the mechanisms by which it is activated are not fully elucidated. In this study we investigated the role of...
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