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Article

A mutation that causes ataxia shifts the voltage-dependence of the Scn8a sodium channel.

Neuroreport - 29 Sept 1999

Smith M R, Goldin A L

Abstract excerpt

A mutation of alanine to threonine in the III S4-S5 linker of the mouse Scn8a sodium channel has previously been identified as causing the ataxia in med(jo) mice. The electrophysiological effects of this mutation in Scn8a sodium channels were characterized in Xenopus oocytes. The med(jo) mutation caused a 10 mV positive shift in the voltage dependence of activation, without any significant changes in the kinetics...

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Source

Identifiers

PMID: 10549817
DOI: 10.1097/00001756-199909290-00028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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