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Article

Floxed allele for conditional inactivation of the voltage-gated sodium channel Scn8a (NaV1.6).

Genesis (New York, N.Y. : 2000) - 1 Aug 2004

Levin Stephen I, Meisler Miriam H

Abstract excerpt

The sodium channel gene Scn8a encodes the channel NaV1.6, which is widely distributed in the central and peripheral nervous system. NaV1.6 is the major channel at the nodes of Ranvier in myelinated axons. Mutant alleles of mouse Scn8a result in neurological disorders including ataxia, tremor, paralysis, and dystonia. We generated a floxed allele of Scn8a by inserting loxP sites around the first coding exon. The...

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PMID: 15286995
DOI: 10.1002/gene.20050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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