Article
Function of a minus-end-directed kinesin-like motor protein in mammalian cells.
Journal of cell science - 1 Nov 1999
Matuliene J, Essner R, Ryu J, Hamaguchi Y, Baas P W, Haraguchi T, Hiraoka Y, Kuriyama R
Abstract excerpt
CHO2 is a mammalian minus-end-directed kinesin-like motor protein present in interphase centrosomes/nuclei and mitotic spindle fibers/poles. Expression of HA- or GFP-tagged subfragments in transfected CHO cells revealed the presence of the nuclear localization site at the N-terminal tail. This domain becomes associated with spindle fibers during mitosis, indicating that the tail is capable of interaction with...
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