Article
RNA interference can target pre-mRNA: consequences for gene expression in a Caenorhabditis elegans operon.
Genetics - 1 Nov 1999
Bosher J M, Dufourcq P, Sookhareea S, Labouesse M
Abstract excerpt
In nematodes, flies, trypanosomes, and planarians, introduction of double-stranded RNA results in sequence-specific inactivation of gene function, a process termed RNA interference (RNAi). We demonstrate that RNAi against the Caenorhabditis elegans gene lir-1, which is part of the lir-1/lin-26 operon, induced phenotypes very different from a newly isolated lir-1 null mutation. Specifically, lir-1(RNAi) induced...
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