Article
Enhancement of HERG K+ currents by Cd2+ destabilization of the inactivated state.
Biophysical journal - 1 Nov 1999
Johnson J P, Balser J R, Bennett P B
Abstract excerpt
We have studied the functional effects of extracellular Cd(2+) on human ether-a-go-go-related gene (HERG) encoded K(+) channels. Low concentrations (10-200 microM) of extracellular Cd(2+) increased outward currents through HERG channels; 200 microM Cd(2+) more than doubled HERG currents and altered current kinetics. Cd(2+) concentrations up to 200 microM did not change the voltage dependence of channel...
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