Article
The hypervariable region 1 protein of hepatitis C virus broadly reactive with sera of patients with chronic hepatitis C has a similar amino acid sequence with the consensus sequence.
Virology - 10 Nov 1999
Watanabe K, Yoshioka K, Ito H, Ishigami M, Takagi K, Utsunomiya S, Kobayashi M, Kishimoto H, Yano M, Kakumu S
Abstract excerpt
Hypervariable region 1 (HVR1) proteins of hepatitis C virus (HCV) have been reported to react broadly with sera of patients with HCV infection. However, the variability of the broad reactivity of individual HVR1 proteins has not been elucidated. We assessed the reactivity of 25 different HVR1 proteins (genotype 1b) with sera of 81 patients with HCV infection (genotype 1b) by Western blot. HVR1 proteins reacted...
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