Article
Towards a solution for hepatitis C virus hypervariability: mimotopes of the hypervariable region 1 can induce antibodies cross-reacting with a large number of viral variants.
The EMBO journal - 1 Jul 1998
Puntoriero G, Meola A, Lahm A, Zucchelli S, Ercole B B, Tafi R, Pezzanera M, Mondelli M U, Cortese R, Tramontano A, Galfre' G, Nicosia A
Abstract excerpt
The hypervariable region 1 (HVR1) of the putative envelope protein E2 of hepatitis C virus (HCV) is the most variable antigenic fragment in the whole viral genome and is mainly responsible for the large inter-and intra-individual heterogeneity of the infecting virus. It contains a principal neutralization epitope and has been proposed as the major player in the mechanism of escape from host immune response. Since...
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