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Article

Mutational analysis of acylphosphatase suggests the importance of topology and contact order in protein folding.

Nature structural biology - 1 Nov 1999

Chiti F, Taddei N, White P M, Bucciantini M, Magherini F, Stefani M, Dobson C M

Abstract excerpt

Muscle acylphosphatase (AcP) is a small protein that folds very slowly with two-state behavior. The conformational stability and the rates of folding and unfolding have been determined for a number of mutants of AcP in order to characterize the structure of the folding transition state. The results show that the transition state is an expanded version of the native protein, where most of the native interactions...

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PMID: 10542090
DOI: 10.1038/14890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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