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Article

Biological function in a non-native partially folded state of a protein.

The EMBO journal - 21 May 2008

Bemporad Francesco, Gsponer Joerg, Hopearuoho Harri I, Plakoutsi Georgia, Stati Gianmarco, Stefani Massimo, Taddei Niccolò, Vendruscolo Michele, Chiti Fabrizio

Abstract excerpt

As structural flexibility is known to be required for enzyme catalysis and pattern recognition and a significant fraction of eukaryotic proteins appear to be unfolded or contain unstructured regions, biological activity of conformational states distinct from fully folded structures could be more common than previously thought. By applying a procedure that allows the recovery of enzymatic activity to be monitored...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18451804
DOI: 10.1038/emboj.2008.82
PMCID: PMC2396399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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