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Article

Three key residues form a critical contact network in a protein folding transition state.

Nature - 1 Feb 2001

Vendruscolo M, Paci E, Dobson C M, Karplus M

Abstract excerpt

Determining how a protein folds is a central problem in structural biology. The rate of folding of many proteins is determined by the transition state, so that a knowledge of its structure is essential for understanding the protein folding reaction. Here we use mutation measurements--which determine the role of individual residues in stabilizing the transition state--as restraints in a Monte Carlo sampling...

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PMID: 11214326
DOI: 10.1038/35054591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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