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Article

Viral oncogenes accelerate conversion to immortality of cultured conditionally immortal human mammary epithelial cells.

Oncogene - 1 Apr 1999

Garbe J, Wong M, Wigington D, Yaswen P, Stampfer M R

Abstract excerpt

Our recent studies on the process of immortalization of cultured human mammary epithelial cells (HMEC) have uncovered a previously undescribed, apparently epigenetic step, termed conversion. When first isolated, clonally derived HMEC lines of indefinite lifespan showed little or no telomerase activity or ability to maintain growth in the presence of TGFbeta. Cell populations whose mean terminal restriction...

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Identifiers

PMID: 10327063
DOI: 10.1038/sj.onc.1202523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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