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Telomerase protects cancer-prone human cells from chromosomal instability and spontaneous immortalization.

Cancer biology & therapy - 1 Jan 2000

Elmore Lynne W, Turner Kristi C, Gollahon Lauren S, Landon Melissa R, Jackson-Cook Colleen K, Holt Shawn E

Abstract excerpt

Studies were conducted to directly test whether the introduction of telomerase protects cancer-prone human mammary epithelial cells from chromosomal instability and spontaneous immortalization. Using a model for Li Fraumeni Syndrome (LFS), infection of human telomerase resulted in maintenance of telomere lengths, extension of in vitro lifespan, and prevention of spontaneous immortalization. In stark contrast to...

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PMID: 12432253

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Telomerase protects cancer-prone human cells from chromosomal instability and spontaneous immortalization.PMID 12432253Read ↗

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