Pyrophosphate mediates the effect of certain tRNA mutations on aminoacylation of yeast tRNA(Phe).

doi:10.1093/nar/27.22.4451

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Article

Pyrophosphate mediates the effect of certain tRNA mutations on aminoacylation of yeast tRNA(Phe).

Nucleic acids research - 15 Nov 1999

Khvorova A, Motorin Y, Wolfson A D

Abstract excerpt

The influence of pyrophosphate hydrolysis by inorganic pyrophosphatase on homologous aminoacylation of different yeast tRNA(Phe) mutants was studied. The addition of pyrophosphatase significantly improved the aminoacylation efficiency of tRNA(Phe) structural mutants as well as the mutant with substitution at position 20, while having no effect on the charge of wild-type tRNA(Phe). Aminoacylation of tRNA(Phe)...

Topics

Acylation
Amino Acids
Base Sequence
Diphosphates
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
Pyrophosphatases
RNA, Fungal
RNA, Transfer, Phe
Saccharomyces cerevisiae

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Identifiers

PMID: 10536155
DOI: 10.1093/nar/27.22.4451
PMCID: PMC148729

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