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Article

A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast.

PloS one - 1 Jan 2012

Takami Tomonori, Fang Yue, Zhou Xin, Jaiseng Wurentuya, Ma Yan, Kuno Takayoshi

Abstract excerpt

Currently, statins are the only drugs acting on the mammalian isoprenoid pathway. The mammalian genes in this pathway are not easily amenable to genetic manipulation. Thus, it is difficult to study the effects of the inhibition of various enzymes on the intermediate and final products in the isoprenoid pathway. In fission yeast, antifungal compounds such as azoles and terbinafine are available as inhibitors of...

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Identifiers

PMID: 23145048
DOI: 10.1371/journal.pone.0049004
PMCID: PMC3492200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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