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Article

Interhomolog bias during meiotic recombination: meiotic functions promote a highly differentiated interhomolog-only pathway.

Cell - 19 Sept 1997

Schwacha A, Kleckner N

Abstract excerpt

Meiotic recombination occurs preferentially between homologous nonsister chromatids rather than between sisters, opposite to the bias of mitotic recombinational repair. We have examined formation of joint molecule recombination intermediates (JMs) between homologs and between sisters in yeast strains lacking the meiotic chromosomal protein Red1, the meiotic recA homolog Dmc1, and/or mitotic recA homolog(s),...

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Source

Identifiers

PMID: 9323140
DOI: 10.1016/s0092-8674(00)80378-5

Genes

DMC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Interhomolog bias during meiotic recombination: meiotic functions promote a highly differentiated interhomolog-only pathway.PMID 9323140Read ↗

From meiosis to postmeiotic events: Uncovering the molecular roles of the meiosis‐specific recombinase Dmc1Semantic proximity Read ↗

Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombination.Semantic proximity Read ↗

Mnd1/Hop2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis of budding yeast.Semantic proximity Read ↗

The logic and mechanism of homologous recombination partner choice.Semantic proximity Read ↗

Meiotic cells monitor the status of the interhomolog recombination complex.Semantic proximity Read ↗

Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination.Semantic proximity Read ↗

DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway.Semantic proximity Read ↗

Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice.Semantic proximity Read ↗

A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1.Semantic proximity Read ↗

High copy number suppression of the meiotic arrest caused by a dmc1 mutation: REC114 imposes an early recombination block and RAD54 promotes a DMC1-independent DSB repair pathway.Semantic proximity Read ↗

Budding yeast Hed1 down-regulates the mitotic recombination machinery when meiotic recombination is impaired.Semantic proximity Read ↗

Small Rad51 and Dmc1 Complexes Often Co-occupy Both Ends of a Meiotic DNA Double Strand Break.Semantic proximity Read ↗

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