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Article

Budding yeast Hed1 down-regulates the mitotic recombination machinery when meiotic recombination is impaired.

Genes & development - 1 Jul 2006

Tsubouchi Hideo, Roeder G Shirleen

Abstract excerpt

In budding yeast, there are two RecA homologs: Rad51 and Dmc1. While Rad51 is involved in both mitotic and meiotic recombination, Dmc1 participates specifically in meiotic recombination. Here, we describe a meiosis-specific protein (Hed1) with a novel Rad51 regulatory function. Several observations indicate that Hed1 attenuates Rad51 activity when Dmc1 is absent. First, although double-strand breaks are normally...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16818607
DOI: 10.1101/gad.1422506
PMCID: PMC1522073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Budding yeast Hed1 down-regulates the mitotic recombination machinery when meiotic recombination is impaired.PMID 16818607Read ↗

Novel attributes of Hed1 affect dynamics and activity of the Rad51 presynaptic filament during meiotic recombination.Semantic proximity Read ↗

From meiosis to postmeiotic events: Uncovering the molecular roles of the meiosis‐specific recombinase Dmc1Semantic proximity Read ↗

DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway.Semantic proximity Read ↗

Saccharomyces cerevisiae recA homologues RAD51 and DMC1 have both distinct and overlapping roles in meiotic recombination.Semantic proximity Read ↗

Down-regulation of Rad51 activity during meiosis in yeast prevents competition with Dmc1 for repair of double-strand breaks.Semantic proximity Read ↗

Tid1/Rdh54 promotes dissociation of Dmc1 from nonrecombinogenic sites on meiotic chromatin.Semantic proximity Read ↗

A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1.Semantic proximity Read ↗

DMC1 attenuates RAD51-mediated recombination in ArabidopsisSemantic proximity Read ↗

Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis.Semantic proximity Read ↗

Red-Hed regulation: recombinase Rad51, though capable of playing the leading role, may be relegated to supporting Dmc1 in budding yeast meiosis.Semantic proximity Read ↗

RAD51 supports DMC1 by inhibiting the SMC5/6 complex during meiosis.Semantic proximity Read ↗

Mnd1/Hop2 facilitates Dmc1-dependent interhomolog crossover formation in meiosis of budding yeast.Semantic proximity Read ↗

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