Fieller's theorem and linkage disequilibrium mapping.

Abstract excerpt

Linkage disequilibrium mapping exploits the fact that at genetic markers close enough to a disease locus on a particular chromosome, we expect to find an association between the disease and marker alleles. Furthermore, the magnitude of the association is expected to follow a unimodal curve when plotted against location, with the peak at the disease location. In practice, for real data, we usually see deviations...

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