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Article

Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2000

Huszar D, Varban M L, Rinninger F, Feeley R, Arai T, Fairchild-Huntress V, Donovan M J, Tall A R

Abstract excerpt

Scavenger receptor BI (SR-BI) is a multiligand cell-surface receptor that plays a central role in high density lipoprotein homeostasis in rodents. To investigate a role for SR-BI in atherosclerosis, mice with attenuated SR-BI expression were crossed with low density lipoprotein (LDL) receptor-deficient mice. Compound-homozygous mutants showed increased plasma cholesterol, surprisingly due primarily to increased...

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Source

Identifiers

PMID: 10764675
DOI: 10.1161/01.atv.20.4.1068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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