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Article

Cerebrovascular responses in mice deficient in the potassium channel, TREK-1.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Aug 2010

Namiranian Khodadad, Lloyd Eric E, Crossland Randy F, Marrelli Sean P, Taffet George E, Reddy Anilkumar K, Hartley Craig J, Bryan Robert M

Abstract excerpt

We tested the hypothesis that TREK-1, a two-pore domain K channel, is involved with dilations in arteries. Because there are no selective activators or inhibitors of TREK-1, we generated a mouse line deficient in TREK-1. Endothelium-mediated dilations were not different in arteries from wild-type (WT) and TREK-1 knockout (KO) mice. This includes dilations of the middle cerebral artery to ATP, dilations of the...

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Identifiers

PMID: 20357027
DOI: 10.1152/ajpregu.00057.2010
PMCID: PMC2928619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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