Article
Emergence of zidovudine and multidrug-resistance mutations in the HIV-1 reverse transcriptase gene in therapy-naive patients receiving stavudine plus didanosine combination therapy. STADI Group.
AIDS (London, England) - 10 Sept 1999
Pellegrin I, Izopet J, Reynes J, Denayrolles M, Montes B, Pellegrin J L, Massip P, Puel J, Fleury H, Segondy M
Abstract excerpt
OBJECTIVE: Assessment of genotypic changes in the reverse transcriptase gene of HIV-1 occurring in antiretroviral naive patients treated by stavudine plus didanosine combination therapy. METHODS: Sequence analysis (codons 1-230) was performed after amplification of the reverse transcriptase gene from plasma samples collected at baseline and at the end of treatment from 39 previously treatment-naive patients...
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