Article
Impact of stavudine phenotype and thymidine analogues mutations on viral response to stavudine plus lamivudine in ALTIS 2 ANRS trial.
Antiviral therapy - 1 Sept 2002
Calvez Vincent, Costagliola Dominique, Descamps Diane, Yvon Anne, Collin Gilles, Cécile Agnès, Delaugerre Constance, Damond Florence, Marcelin Anne-Geneviève, Matheron Sophie, Simon Anne, Valantin Marc-Antoine, Katlama Christine, Brun-Vézinet Françoise
Abstract excerpt
OBJECTIVE: Stavudine-based antiretroviral combinations are less effective in zidovudine-experienced patients than in naive subjects and recently, mutations have been described to be associated to the use of both stavudine and zidovudine. In the ALTIS 2 trial, it was shown that a combination of stavudine and lamivudine is less effective in zidovudine-experienced patients than in naive patients. We conducted a...
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