Article
A Forward Genetic Approach to Mapping a P-Element Second Site Mutation Identifies DCP2 as a Novel Tumor Suppressor in Drosophila melanogaster.
G3 (Bethesda, Md.) - 5 Aug 2020
Mishra Rakesh, Kunar Rohit, Mandal Lolitika, Alone Debasmita Pankaj, Chandrasekharan Shanti, Tiwari Anand Krishna, Tapadia Madhu Gwaldas, Mukherjee Ashim, Roy Jagat Kumar
Abstract excerpt
The use of transposons to create mutations has been the cornerstone of Drosophila genetics in the past few decades. Second-site mutations caused by transpositions are often devoid of transposons and thereby affect subsequent analyses. In a P-element mutagenesis screen, a second site mutation was identified on chromosome 3, wherein the homozygous mutants exhibit classic hallmarks of tumor suppressor mutants,...
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