Article
Mutation distribution in the NSP4 protein in rotaviruses isolated from Mexican children with moderate to severe gastroenteritis.
Viruses - 11 Mar 2013
González-Ochoa Guadalupe, Menchaca Griselda E, Hernández Carlos E, Rodríguez Cristina, Tamez Reyes S, Contreras Juan F
Abstract excerpt
The NSP4 protein is a multifunctional protein that plays a role in the morphogenesis and pathogenesis of the rotavirus. Although NSP4 is considered an enterotoxin, the relationship between gastroenteritis severity and amino acid variations in NSP4 of the human rotavirus remains unclear. In this study, we analyzed the sequence diversity of NSP4 and the severity of gastroenteritis of children with moderate to...
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