Article
Characterization of Neurospora crassa mutants isolated following repeat-induced point mutation of the beta subunit of fatty acid synthase.
Current genetics - 1 Sept 1999
Goodrich-Tanrikulu M, Jacobson D J, Stafford A E, Lin J T, McKeon T A
Abstract excerpt
Neurospora crassa cel-2 mutants were isolated following repeat-induced point mutation using part of the gene encoding beta-fatty acid synthase. These mutants are phenotypically less leaky than cel-1, which has a defective alpha-fatty acid synthase. The cel-2 mutant had a strict fatty acid (16:0) requirement for growth, and synthesized less fatty acid de novo than cel-1. Unlike cel-1, cel-2 has impaired fertility,...
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