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Article

IL-18 binding and inhibition of interferon γ induction by human poxvirus-encoded proteins

28 Sept 1999

Abstract excerpt

Molluscum contagiosum virus (MCV) is a common, human poxvirus that causes small papular skin lesions that persist for long periods without signs of inflammation. Previous studies revealed that MCV encodes a family of proteins with homology to mammalian IL-18 binding proteins. IL-18 is a proinflammatory cytokine that induces synthesis of interferon gamma, activates NK cells, and is required for a T-lymphocyte...

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PMID: 10500212
DOI: 10.1073/pnas.96.20.11537

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