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The highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon

17 Dec 2009

Abstract excerpt

Variola virus (VARV) caused smallpox, one of the most devastating human diseases and the first to be eradicated, but its deliberate release represents a dangerous threat. Virulent orthopoxviruses infecting humans, such as monkeypox virus (MPXV), could fill the niche left by smallpox eradication and the cessation of vaccination. However, immunomodulatory activities and virulence determinants of VARV and MPXV...

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PMID: 20019241
DOI: 10.1096/fj.09-144733

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