Article
Reassessment of the location of the thyrotropin receptor 50 amino acid "insertion" provides evidence in favor of a second downstream cleavage site.
Thyroid : official journal of the American Thyroid Association - 1 Feb 2001
Tanaka K, Chazenbalk G D, Rapoport B, McLachlan S M
Abstract excerpt
Cleavage of thyrotropin receptors (TSHR) on the cell surface into disulfide-linked A and B subunits involves deletion of an intervening region that corresponds approximately to a 50 amino acid "insertion" in the TSHR relative to the noncleaving luteinizing hormone/choriogonadotropin receptor (LH/CGR). The location of this insertion is imprecise because of the relatively low homology between the two receptors in...
Topics
- Amino Acid Sequence
- Animals
- CHO Cells
- Cricetinae
- Cross-Linking Reagents
- DNA Transposable Elements
- Gene Deletion
- Molecular Sequence Data
- Mutation
- Receptors, Thyrotropin