Thyrotropin receptor cleavage at site 1 involves two discontinuous segments at each end of the unique 50-amino acid insertion.

doi:10.1074/jbc.274.4.2093

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Article

Thyrotropin receptor cleavage at site 1 involves two discontinuous segments at each end of the unique 50-amino acid insertion.

The Journal of biological chemistry - 22 Jan 1999

Tanaka K, Chazenbalk G D, McLachlan S M, Rapoport B

Abstract excerpt

Among the glycoprotein hormone receptors, only the thyrotropin receptor (TSHR) cleaves (at two sites) into disulfide-linked A and B subunits. A 50-amino acid insertion unique to the TSHR ectodomain (residues 317-366) plays no role in ligand binding or signal transduction, but its deletion abrogat...

Topics

Amino Acid Sequence
Amino Acids
Animals
CHO Cells
Cricetinae
Hydrolysis
Molecular Sequence Data
Mutation
Receptors, Thyrotropin
Sequence Deletion

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