Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Current standards, variations, and pitfalls for the determination of constitutive TSHR activity in vitro.

Methods in enzymology - 1 Jan 2010

Mueller Sandra, Jaeschke Holger, Paschke Ralf

Abstract excerpt

Constitutively activating mutations of the TSHR are the major cause for nonautoimmune hyperthyroidism, which is based on ligand independent, permanent receptor activation. Several reports have highlighted the difficulties to determine whether a TSHR mutation is constitutively active or not especially for borderline cases with only a slight increase of the basal cAMP activity. Current methods to precisely classify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chlorocebus aethiops
Share to COS Cells
Share to Cyclic AMP

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Gene Expression

Share to Linear Models

Share to Radioligand Assay

Share to Receptors, Thyrotropin

Source

Identifiers

PMID: 21050930
DOI: 10.1016/B978-0-12-381296-4.00023-3

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Current standards, variations, and pitfalls for the determination of constitutive TSHR activity in vitro.PMID 21050930Read ↗

Controversial constitutive TSHR activity: patients, physiology, and in vitro characterization.Semantic proximity Read ↗

Constitutive activities in the thyrotropin receptor: regulation and significance.Semantic proximity Read ↗

Constitutive TSH receptor activation as a hallmark of thyroid autonomy.Semantic proximity Read ↗

Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas.Semantic proximity Read ↗

Shared sporadic and somatic thyrotropin receptor mutations display more active in vitro activities than familial thyrotropin receptor mutations.Semantic proximity Read ↗

Mutations in the mouse TSH receptor equivalent to human constitutively activating TSH receptor mutations also cause constitutive activity.Semantic proximity Read ↗

The extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design.Semantic proximity Read ↗

Lack of consistent association of thyrotropin receptor mutations in vitro activity with the clinical course of patients with sporadic non-autoimmune hyperthyroidism.Semantic proximity Read ↗

Identification and evaluation of constitutively active thyroid stimulating hormone receptor mutations.Semantic proximity Read ↗

[The multifaceted TSH receptor].Semantic proximity Read ↗

Identification and functional characterization of two novel activating thyrotropin receptor mutants in toxic thyroid follicular adenomas.Semantic proximity Read ↗

The TSH receptor and thyroid diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.