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Article

The impact of misclassification in case-control studies of gene-environment interactions.

IARC scientific publications - 1 Jan 1999

Rothman N, Garcia-Closas M, Stewart W T, Lubin J

Abstract excerpt

In this chapter we describe the impact of risk factor misclassification in case-control studies designed to estimate gene-environment interactions. We show that under certain scenarios even small amounts of exposure or genotype misclassification can substantially attenuate the interaction effect and, as a consequence, dramatically increase the sample size required to study these interactions. A consideration of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10493251

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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