Article
The impact of genotype misclassification errors on the power to detect a gene-environment interaction using cox proportional hazards modeling.
Human heredity - 1 Jan 2007
Tung Lin, Gordon Derek, Finch Stephen J
Abstract excerpt
This paper extends gene-environment (G x E) interaction study designs in which the gene (G) is known and the environmental variable (E) is specified to the analysis of 'time-to-event' data, using Cox proportional hazards (PH) modeling. The objectives are to assess whether a random sample of subjects can be used to detect a specific G x E interaction and to study the sensitivity of the power of PH modeling to...
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