Article
Tumour predisposition and cancer syndromes as models to study gene-environment interactions.
Nature reviews. Cancer - 1 Sept 2020
Carbone Michele, Arron Sarah T, Beutler Bruce, Bononi Angela, Cavenee Webster, Cleaver James E, Croce Carlo M, D'Andrea Alan, Foulkes William D, Gaudino Giovanni, Groden Joanna L, Henske Elizabeth P, Hickson Ian D, Hwang Paul M, Kolodner Richard D, Mak Tak W, Malkin David, Monnat Raymond J, Novelli Flavia, Pass Harvey I, Petrini John H, Schmidt Laura S, Yang Haining
Abstract excerpt
Cell division and organismal development are exquisitely orchestrated and regulated processes. The dysregulation of the molecular mechanisms underlying these processes may cause cancer, a consequence of cell-intrinsic and/or cell-extrinsic events. Cellular DNA can be damaged by spontaneous hydrolysis, reactive oxygen species, aberrant cellular metabolism or other perturbations that cause DNA damage. Moreover,...
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