Biomarkers of inherited susceptibility and cancer.

Abstract excerpt

The etiology of cancer is likely to involve the effects of inherited genotypes at various points in the multistage process of carcinogenesis. For example, inherited genotypes could influence propensity to be exposed to carcinogens, generation of somatic mutations that initiate tumours, determination of a tumour's natural history or clinical prognosis and response to chemoprevention and treatment. Classes of...

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