Article
A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-gamma receptor 1 gene associated with allergic diseases.
International journal of molecular medicine - 1 Aug 2003
Aoki Minako, Matsui Eiko, Kaneko Hideo, Inoue Ryosuke, Fukao Toshiyuki, Watanabe Mizuho, Teramoto Takahide, Kato Zenichiro, Suzuki Kiyotaka, Suzuki Yasuyuki, Kasahara Kimiko, Kondo Naomi
Abstract excerpt
We identified a novel heterozygous single-nucleotide substitution 1400 T right curved arrow C (Leu 467 Pro) in the seventh exon of the interferon-gamma receptor 1 (IFNGR1) gene. This substitution was detected in 6 of the 89 allergic patients but not in the 72 non-allergic subjects. There was a difference in the L467P frequency between the allergic patients and the non-allergic subjects (Fisher's exact test:...
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