Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulation of aldosterone biosynthesis by adrenodoxin mutants with different electron transport efficiencies.

European journal of biochemistry - 1 Oct 1999

Cao P R, Bernhardt R

Abstract excerpt

Aldosterone biosynthesis is highly regulated on different levels by hormones, potassium, lipid composition of the membrane and the molecular structure of its gene. Here, the influence of the electron transport efficiency from adrenodoxin (Adx) to CYP11B1 on the activities of bovine CYP11B1 has been investigated using a liposomal reconstitution system with truncated mutants of Adx. It could be clearly demonstrated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldosterone
Share to Corticosterone
Share to Cytochrome P-450 CYP11B2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport

Share to Ferredoxin-NADP Reductase

Share to Hydroxylation

Share to Liposomes

Share to Steroid 11-beta-Hydroxylase

Source

Identifiers

PMID: 10491169
DOI: 10.1046/j.1432-1327.1999.00704.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulation of aldosterone biosynthesis by adrenodoxin mutants with different electron transport efficiencies.PMID 10491169Read ↗

The interaction of bovine adrenodoxin with CYP11A1 (cytochrome P450scc) and CYP11B1 (cytochrome P45011beta ). Acceleration of reduction and substrate conversion by site-directed mutagenesis of adrenodoxin.Semantic proximity Read ↗

Structure of adrenodoxin and function in mitochondrial steroid hydroxylation.Semantic proximity Read ↗

Modulation of aldosterone and cortisol synthesis on the molecular level.Semantic proximity Read ↗

Kinetic and optical biosensor study of adrenodoxin mutant AdxS112W displaying an enhanced interaction towards the cholesterol side chain cleavage enzyme (CYP11A1).Semantic proximity Read ↗

Cloning of CYP11B1 and CYP11B2 from normal human adrenal and their functional expression in COS-7 and V79 chinese hamster cellsSemantic proximity Read ↗

Fission yeast Schizosaccharomyces pombe as a new system for the investigation of corticosterone methyloxidase deficiency-causing mutations.Semantic proximity Read ↗

Conferring aldosterone synthesis to human CYP11B1 by replacing key amino acid residues with CYP11B2‐specific onesSemantic proximity Read ↗

Testosterone inhibits human wild-type and chimeric aldosterone synthase activity in vitroSemantic proximity Read ↗

Recombinant<i>CYP11B</i>Genes Encode Enzymes that Can Catalyze Conversion of 11-Deoxycortisol to Cortisol, 18-Hydroxycortisol, and 18-Oxocortisol<sup>1</sup>Semantic proximity Read ↗

YAH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to human adrenodoxin.Semantic proximity Read ↗

Cytochrome b5 modulates multiple reactions in steroidogenesis by diverse mechanisms.Semantic proximity Read ↗

Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.