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Article

Recombinant<i>CYP11B</i>Genes Encode Enzymes that Can Catalyze Conversion of 11-Deoxycortisol to Cortisol, 18-Hydroxycortisol, and 18-Oxocortisol<sup>1</sup>

1 Nov 1998

Abstract excerpt

CYP11B1 (11beta-hydroxylase) and CYP11B2 (aldosterone synthase) are 93% identical mitochondrial enzymes that both catalyze 11beta-hydroxylation of steroid hormones. CYP11B2 has the additional 18-hydroxylase and 18-oxidase activities required for conversion of 11-deoxycorticosterone to aldosterone. These two additional C18 conversions can be catalyzed by CYP11B1 if serine-288 and valine-320 are replaced by the...

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Identifiers

PMID: 9814482
DOI: 10.1210/jcem.83.11.5237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Recombinant<i>CYP11B</i>Genes Encode Enzymes that Can Catalyze Conversion of 11-Deoxycortisol to Cortisol, 18-Hydroxycortisol, and 18-Oxocortisol<sup>1</sup>PMID 9814482Read ↗

Disorders of steroid 11 beta-hydroxylase isozymes.Semantic proximity Read ↗

Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.Semantic proximity Read ↗

Mutations in the human CYP11B2 (aldosterone synthase) gene causing corticosterone methyloxidase II deficiency.Semantic proximity Read ↗

Genetic recombination as a cause of inherited disorders of aldosterone and cortisol biosynthesis and a contributor to genetic variation in blood pressure.Semantic proximity Read ↗

11 beta-Hydroxysteroid dehydrogenase.Semantic proximity Read ↗

Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.Semantic proximity Read ↗

Molecular biology of 11β-hydroxylase and 11β-hydroxysteroid dehydrogenase enzymes.Semantic proximity Read ↗

Steroid 11 beta-hydroxylase deficiency and related disorders.Semantic proximity Read ↗

Isolated aldosterone synthase deficiency caused by simultaneous E198D and V386A mutations in the CYP11B2 gene.Semantic proximity Read ↗

Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies.Semantic proximity Read ↗

Deletion Hybrid Genes, due to Unequal Crossing Over betweenCYP11B1(11β-Hydroxylase) andCYP11B2(Aldosterone Synthase) Cause Steroid 11β-Hydroxylase Deficiency and Congenital Adrenal Hyperplasia1Semantic proximity Read ↗

Functional effects of genetic variants in the 11beta-hydroxylase (CYP11B1) gene.Semantic proximity Read ↗

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