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Conferring aldosterone synthesis to human CYP11B1 by replacing key amino acid residues with CYP11B2‐specific ones

15 Mar 1998

Abstract excerpt

Performing residue-swapping experiments between the highly conserved human steroidogenic proteins CYP11B1 and CYP11B2 we recently demonstrated that replacement of specific residues at position 301, 302 and 320 in the aldosterone-producing CYP11B2 protein for such residues that were specific for the highly similar cortisol-producing CYP11B1 protein elevated the 11beta-hydroxylase activity dramatically. Conversely,...

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Identifiers

PMID: 9546661
DOI: 10.1046/j.1432-1327.1998.2520458.x

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