Article

Testosterone inhibits human wild-type and chimeric aldosterone synthase activity in vitro

2020-10-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Familial hyperaldosteronism type I is caused by the generation of a chimeric aldosterone synthase enzyme (ASCE) which is regulated by ACTH instead of angiotensin II. We have reported that in vitro, the wild-type (ASWT) and chimeric aldosterone synthase (ASCE) enzymes are inhibited by progesterone and estradiol did not affect.<bold>Aim</bold>To explore the direct a...

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Literature Corpus work: b686c583-691a-5277-b3b9-012009ef1dc2
DOI: 10.21203/rs.3.rs-51648/v1

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