Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.

Biochemistry - 2 May 2017

Peng Hwei-Ming, Auchus Richard J

Abstract excerpt

The mitochondrial cytochromes P450 11B1 and P450 11B2 are responsible for the final stages of cortisol and aldosterone synthesis, respectively. Dysregulation of both enzymes has been implicated in secondary forms of hypertension. Molecular recognition of the cytochromes P450 with their corresponding redox partner is a key step in the catalytic cycle, yet the precise nature of the interaction of P450 11B1 or P450...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Cortex Hormones
Share to Biocatalysis
Share to Cross-Linking Reagents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP11B2

Share to Ferredoxin-NADP Reductase

Share to Ferredoxins

Share to Static Electricity

Share to Steroid 11-beta-Hydroxylase

Source

Open in PubMed Open full text

Identifiers

PMID: 28355486
DOI: 10.1021/acs.biochem.7b00034
PMCID: PMC8624949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular Recognition in Mitochondrial Cytochromes P450 That Catalyze the Terminal Steps of Corticosteroid Biosynthesis.PMID 28355486Read ↗

Congenital Adrenal Hyperplasia Due to 11-Hydroxylase Deficiency: Functional Characterization of Two Novel Point Mutations and a Three-Base Pair Deletion in theCYP11B1GeneSemantic proximity Read ↗

Kinetic and optical biosensor study of adrenodoxin mutant AdxS112W displaying an enhanced interaction towards the cholesterol side chain cleavage enzyme (CYP11A1).Semantic proximity Read ↗

Modulation of aldosterone and cortisol synthesis on the molecular level.Semantic proximity Read ↗

Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristicsSemantic proximity Read ↗

Conferring aldosterone synthesis to human CYP11B1 by replacing key amino acid residues with CYP11B2‐specific onesSemantic proximity Read ↗

Testosterone inhibits human wild-type and chimeric aldosterone synthase activity in vitroSemantic proximity Read ↗

The cytochrome P450 24A1 interaction with adrenodoxin relies on multiple recognition sites that vary among species.Semantic proximity Read ↗

The interaction of bovine adrenodoxin with CYP11A1 (cytochrome P450scc) and CYP11B1 (cytochrome P45011beta ). Acceleration of reduction and substrate conversion by site-directed mutagenesis of adrenodoxin.Semantic proximity Read ↗

Modulation of aldosterone biosynthesis by adrenodoxin mutants with different electron transport efficiencies.Semantic proximity Read ↗

Proteomics, modeling, and fluorescence assays delineate cytochrome b5 residues involved in binding and stimulation of cytochrome P450 17A1 17,20-lyase.Semantic proximity Read ↗

Protein phosphorylation and intermolecular electron transfer: a joint experimental and computational study of a hormone biosynthesis pathway.Semantic proximity Read ↗

Recombinant<i>CYP11B</i>Genes Encode Enzymes that Can Catalyze Conversion of 11-Deoxycortisol to Cortisol, 18-Hydroxycortisol, and 18-Oxocortisol<sup>1</sup>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.