Article
Modulation of aldosterone and cortisol synthesis on the molecular level.
Molecular and cellular endocrinology - 27 Feb 2004
Lisurek Michael, Bernhardt Rita
Abstract excerpt
CYP11B1 and the closely related CYP11B2 are involved in the production of adrenal steroid hormones. Although in human their primary structure is 93% identical they are involved in the biosynthesis of functionally diverse products, such as glucocorticoids and mineralocorticoids, respectively. In contrast, bovine CYP11B1 combines both activities in one single enzyme. The CYP11B family belongs to class I cytochromes...
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