Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx.

doi:10.1038/sj.onc.1202867

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Article

Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx.

Oncogene - 26 Aug 1999

Sirma H, Giannini C, Poussin K, Paterlini P, Kremsdorf D, Bréchot C

Abstract excerpt

Chronic infection by HBV is the leading cause of hepatocellular carcinoma in man. Several lines of evidence suggest that the viral transactivator HBx plays a critical role in the molecular pathogenesis of HBV-related HCC. To study the actual impact of HBx and the mechanism of its action, we have...

Topics

Amino Acid Sequence
Animals
Carcinoma, Hepatocellular
Cell Cycle
Cell Differentiation
Cell Division
Cells, Cultured
G1 Phase
Humans
Liver
Liver Neoplasms
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Stem Cells

Trans-Activators

Transcription, Genetic

Transcriptional Activation

Source

Open in PubMed

Identifiers

PMID: 10490818
DOI: 10.1038/sj.onc.1202867

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-10490818-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx.PMID 10490818Read ↗

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Modulation of Apoptotic Signaling by the Hepatitis B Virus X ProteinSemantic proximity Read ↗

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Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis.Semantic proximity Read ↗

Stimulation of Cellular Proliferation by Hepatitis B Virus X ProteinSemantic proximity Read ↗

The proapoptotic effect of hepatitis B virus HBx protein correlates with its transactivation activity in stably transfected cell lines.Semantic proximity Read ↗

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