Article
Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily.
Molecular and cellular biology - 1 May 1999
Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum S P, Renkawitz R, Baniahmad A
Abstract excerpt
Some members of nuclear hormone receptors, such as the thyroid hormone receptor (TR), silence gene expression in the absence of the hormone. Corepressors, which bind to the receptor's silencing domain, are involved in this repression. Hormone binding leads to dissociation of corepressors and binding of coactivators, which in turn mediate gene activation. Here, we describe the characteristics of Alien, a novel...
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