Article
Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors.
American journal of human genetics - 1 Oct 1999
Varley J M, McGown G, Thorncroft M, James L A, Margison G P, Forster G, Evans D G, Harris M, Kelsey A M, Birch J M
Abstract excerpt
We have analyzed a panel of 14 cases of childhood adrenocortical tumors unselected for family history and have identified germline TP53 mutations in >80%, making this the highest known incidence of a germline mutation in a tumor-suppressor gene in any cancer. The spectrum of germline TP53 mutations detected is remarkably limited. Analysis of tumor tissue for loss of constitutional heterozygosity, with respect to...
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