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Article

TP53-Associated Pediatric Malignancies

1 Apr 2011

Abstract excerpt

Although the majority of pediatric malignancies express wild-type p53, it is well established that germline TP53 mutations or functional inactivation of this pathway by other means contribute to childhood cancer. Epidemiology studies have revealed the existence of diverse inherited mutant TP53 alleles that display different levels of tumor suppressor activity, which correlate with cancer risk in terms of...

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PMID: 21779516
DOI: 10.1177/1947601911409745

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